Submitter Withdrawn Australian Diabetes Society and the Australian Diabetes Educators Association Annual Scientific Meeting 2016

Higher maternal serum prolactin levels are associated with reduced glucose tolerance during pregnancy (#315)

Elif I. Ekinci 1 2 3 , Niloufar Torkamani 1 4 , Sabashini Ramchand 2 , Leonid Churilov 5 , Ken Sikaris 6 , Zhong Lu 6 7 , Chris Houlihan 2 8
  1. Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia
  2. Department of Endocrinology, Austin Health, Melbourne, VIC, Australia
  3. Menzies School of Health Research, Darwin, NT, Australia
  4. Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia
  5. Florey Institute of Neuroscience and Mental Health ,, University of Melbourne , Melbourne, VIC, Australia
  6. Department of Chemical Pathology, Melbourne Pathology, Melbourne, VIC, Australia
  7. Department of Medicine, Monash University, Melbourne, VIC, Australia
  8. Mercy Hospital for Women, Melbourne, VIC, Australia

Aims/hypothesis It is unclear if increased prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy.


Methods 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-hour glucose levels.


Results Multivariable regression analysis demonstrated an independent and significant relationship between third trimester prolactin and 2-hour glucose levels post OGTT. Higher prolactin levels were associated with higher glucose levels independent of age, BMI, gravidity and parity.



Higher prolactin levels are associated with reduced glucose tolerance in the third trimester of pregnancy. This suggests possible independent role of prolactin in the pathogenesis of gestational diabetes.